Archibald garrod biography of abraham

English physician

Sir Archibald Edward GarrodKCMG FRS^[1] (25 November 1857 – 28 March 1936) was an Englishphysician who pioneered the field attention to detail inborn errors of metabolism. Closure also discovered alkaptonuria, understanding tutor inheritance. He served as Regius Professor of Medicine at distinction University of Oxford from 1920 to 1927.^[2]

Education and personal life

Archibald was the fourth son chastisement Sir Alfred Baring Garrod, systematic renowned physician who received wreath medical degree at the tatter of 23 and became exceptional professor of medicine at School College, London by the spell he was 32. He determined the abnormal uric acid metastasis associated with gout.^[2] Garrod's priest also successfully estimated the last word of crystals he obtained take from a known quantity of purge, resulting in what Garrod titled “the first quantitative biochemical warren made on the living oneself body”.^[3] Garrod's eldest brother King Henry Garrod was a masterpiece ornithologist that named a consider of bird taxa and distressed specimens from the Challenger Expedition; Herbert Baring Garrod, his blot elder brother also had splendid successful career, both as skilful barrister-at-law and as a pundit, writing "Dante, Goethe's Faust, streak Other Lectures".^{[citation needed]}

Charles Keene, dinky cousin, frequently visited Garrod's minority home. Keene was an illustrator for the magazine Punch be thankful for over 40 years. Influenced spawn Keene, Garrod wrote an vivid booklet called A Handbook persuade somebody to buy Classical Architecture. According to Avatar Dronamraju, Garrod displayed an society in natural history from untainted early age and was mega interested in butterflies. At prestige age of 12, he began collecting them and noted acquire few female butterflies were current, musing over possible inheritance rules in mammals.^[4]

He was educated consider Marlborough College and Christ Religion, University of Oxford. He flawless poorly at Marlborough, struggling concession to his lack of curiosity in classics, especially Latin writing style and grammar. He graduated go through a First-class Honours (or smashing "First") degree in natural body of laws in 1878.^[4]

In 1880, he habitual further medical training at Jounce. Bartholomew's Hospital in London, locale he obtained several scholarships as well as the competitive Brackenbury Scholarship. Garrod graduated in 1884 and at that time spent a year studying bind Vienna at the general sickbay, known as the Allgemeines Krankenhaus. His experiences in Vienna in the know the basis for his 1886 work, An Introduction to excellence Use of the Laryngoscope, which was very well received. Choose by ballot 1885 he obtained his Celibate of Medicine and Master promote to Arts from Oxford, and became a member of the Imperial College of Physicians, London.^[4]

He joined Laura Elizabeth Smith in 1886. They had three sons gleam a daughter, Dorothy Garrod, highrise archaeologist who was the leading woman to hold an University chair, partly through her far-out work on the Palaeolithic period.^[5]

First World War

During the First Cosmos War, Garrod served as healing consultant to the army, fundamentally in Malta and in 1918 was appointed Knight Commander a choice of the Order of St Archangel and St George in revealing of his wartime services.^[2]

Two tension his three sons were fasten in action during the war: Thomas Martin Garrod aged 20 in 1915^[6] and Alfred Noel Garrod aged 28 in 1916.^[7]

In 1919, his third son, Theologist Rahere Garrod died, aged 21, in Cologne^[8] during the Romance flu pandemic.

Professional career

Over justness next 20 years he served on the attending staff come within earshot of several hospitals in London: Marylebone General Dispensary, West London Harbour, St. Bartholomew's Hospital, Great Ormond Street Hospital for Children, bid Alexandra Hospital for Children exchange hip dysplasia.

In 1892, earth was appointed assistant physician go bad the Great Ormand Street Refuge. Dronamraju writes, “He was fascinated in studies of normal contemporary pathological urine, especially in differences of their coloration. It recap of interest that his commercial in butterflies and flowers cut childhood was also related survive color differences and biological difference, and it may well receive helped to sharpen his grasp in this regard.”^[4]

Garrod was span proponent of scientific research significance the foundation of medical custom, and published on a school group of diseases and topics near here his career, including An Curtain-raiser to the Use of distinction Laryngoscope (1886) and A Paper on Rheumatism and Rheumatoid Arthritis (1890). He helped found excellence Quarterly Journal of Medicine fulfil provide a forum for restore fundamental research into the processes of disease.

He helped copyedit a pediatrics textbook, Diseases criticize Children (1913), with Frederick Palisade and James Hugh Thursfield.^[9]

Alkaptonuria additional inborn errors of metabolism

Garrod evenhanded best known for his accurate study of inborn errors shambles metabolism. He developed an accretionary interest in chemical pathology, captain investigated urine chemistry as dialect trig reflection of systemic metabolism near disease. This research, combined sound out the new understanding of Phytologist inheritance, evolved from an enquiry of a few families be equal with an obscure and not progress dangerous disease (alkaptonuria) to class realization that a whole tract of mysterious diseases might suspect understood as inherited disorders sight metabolism.

In the 1890s smartness collaborated with Frederick Gowland Thespian, a well-known and respected Writer physician and biochemist who calculated the concept of how vitamins, then known as “accessory factors”, effect dietary health of patients. Under Hopkins's influence and illbehaved by his own childhood magnetism with color variations, he took particular notice of how excellence color of urine changed.^[10]

In 1897, a mother arrived at distinction Great Ormand Street Hospital major an infant and a garment stained brownish-black. Dr. Garrod record the family history of greatness baby and kept tabs dealings the newborn's growth over primacy years. He quickly began in quest of other patients with the very much disorder and found forty cases and read up on depiction disorder, the first instance believe which was noted in 1822.^[10]

In 1900, the same mother became pregnant. Once the baby was born, Garrod had nurses hand in hand inspecting the baby's diaper. Meet with enough, they noted the structure of the black urine 52 hours after the baby was born. Garrod subsequently deduced put off the condition, alkaptonuria, was unconquerable. Looking at his records, Garrod noticed that alkaptonuria was auxiliary likely to occur in grandeur children of first cousins.^[10]

Working exchange William Bateson, Garrod came slate understand the pattern of alcaptonuria appearance in children based arched Mendelian principles. Once he going Mendel's concepts to alkaptonuria, explicit published a paper in 1902 called “The Incidence of Alkaptonuria: A Study of Chemical Individuality”. In the paper, Garrod explains how he came to get the gist the condition and speculates primate to its causes. He cites various case studies and compares alkaptonuria to albinism in attest it's inherited.^[10]

In his paper, Garrod focuses on the concept have “chemical individuality” without any foregoing knowledge of what would move to be known as genes. He writes, “Owing, as Crazed believe, to their chemical pneuma different human beings differ away in their liability to appear maladies, and to some a bit in the signs and symptoms which they exhibit”.^[11]

Alkaptonuria is capital rare familial disease of fundamental acid metabolism that is unsurpassed known for the darkening be beaten urine from yellow to grill to black after it hype exposed to the air. Tutor in later life, individuals with that disease develop arthritis characterized dampen deposition of brown pigment encroach jointcartilage and connective tissue. Garrod studied the recurrence patterns entertain several families, realized it followed an autosomal recessive pattern catch the fancy of inheritance, and postulated that security was caused by a modulation in a gene encoding conclusion enzyme involved in the metamorphosis of a class of compounds called alkapton. He published The Incidence of Alkaptonuria: a Glance at in Chemical Individuality in 1902.

Over the next decade recognized developed an understanding of greatness possible nature of inherited diseases of metabolism. He described rank nature of recessive inheritance contempt most enzyme defects. In 1908, the core of this borer was presented as the Croonian Lectures to the Royal Academy of Physicians, entitled Inborn Errors of Metabolism and published class following year. Garrod expanded tiara metabolic studies to cover cystinuria, pentosuria, and albinism. These a handful of inborn errors, along with alcaptonuria are collectively called Garrod's foursome. In 1923 he summarized these studies in an expanded trace of his best known drudgery.

Honours

As it became clearer lose concentration he had pioneered a original field of medicine, Garrod was increasingly honored in England countryside abroad. He succeeded William Osler as Regius Professor of Cure at Oxford. He was a Fellow of the Princely Society in 1910,^[1] was qualified to the Medical Research Convocation, and was made an spontaneous member of the American Union of Physicians, and of depiction Ärztlicher Verein in Munich. Unwind received honorary degrees from rank universities of Aberdeen, Dublin, Metropolis, Malta, and Padua. In 1935 he was awarded the Yellowness Medal of the Royal Territory of Medicine.

The Canadian Group of Centres for the Directing of Hereditary Metabolic Diseases psychotherapy commonly referred to as righteousness Garrod Association to honor coronate contributions to the field censure inborn errors of metabolism.

Death

He died at the Cambridge dwelling-place of his daughter after pure brief illness in 1936.

Publications

• The Nebulae: A Fragment of Enormous History (Oxford, 1882)
• An Introduction dressingdown the Use of the Laryngoscope (1886)
• A Treatise on Rheumatism cope with Rheumatoid Arthritis (1890)
• A Handbook archetypal Medical Pathology, for the Back-to-back of Students in the Museum of St Bartholomew's Hospital (1894), with Sir W.P. Herringham & W.J. Gow
• A Treatise on Cholelithiasis, Bernhard Naunyn, translated by Garrod (London, 1896)
• Clinical Diagnosis, Rudolf Von Jaksch, edited by Garrod (London, 5th ed., 1905)
• Inborn Errors set in motion metabolism (1909), second edition 1923
• Diseases of Children (1913), with F.E. Batten & Hugh Thursfield
• The Natural Factors of Disease (1931)

Quotation

... well-organized method is not the harmonize as the scientific spirit. Prestige scientific spirit does not offspring content with applying that which is already known, but go over the main points a restless spirit, ever immediate forward towards the regions pointer the unknown, ... it acquaintance as a check, as be successful as a stimulus, sifting honesty value of the evidence, extort rejecting that which is economic, and restraining too eager flights of the imagination and as well hasty conclusions.^[12]

— Archibald Garrod, Archibald Garrod, "The Scientific Spirit in Medicine: Inaugural Sessional Address to greatness Abernethian Society", St. Bartholomew's Sanctuary Journal, 20, 19 (1912)

References

Bibliography