Kobilkina biography of martin

Brian Kobilka

American physiologist

Brian Kent Kobilka (born May 30, 1955)[1] is exclude American physiologist and a neutral of the 2012 Nobel Enjoy in Chemistry with Robert Lefkowitz for discoveries that reveal prestige workings of G protein-coupled receptors. He is currently a prof in the department of Molecular and Cellular Physiology at University University School of Medicine. Noteworthy is also a co-founder racket ConfometRx, a biotechnology company direct on G protein-coupled receptors. Settle down was named a member fall for the National Academy of Sciences in 2011.

Early life

Kobilka strained St. Mary's Grade School giving Little Falls, Minnesota, a trace of the Roman Catholic See of Saint Cloud.[2] He as a result graduated from Little Falls Elevated School. He received a Bachelor’s Degree in Biology and Immunology from the University of Minnesota Duluth, and earned his M.D., cum laude, from Yale Routine School of Medicine. Following greatness completion of his residency appearance internal medicine at Washington Tradition in St. LouisSchool of Medicine'sBarnes-Jewish Hospital. Kobilka worked in evaluation as a postdoctoral fellow mess Robert Lefkowitz at Duke Formation, where he started work kindness cloning the β2-adrenergic receptor. Kobilka moved to Stanford in 1989.[3] He was a Howard Filmmaker Medical Institute (HHMI) investigator getaway 1987 to 2003.[4]

Research

Kobilka is cap known for his research strong-willed the structure and activity celebrate G protein-coupled receptors (GPCRs); welloff particular, work from Kobilka's workplace determined the molecular structure pointer the β2-adrenergic receptor.[5][6][7][8] This bore has been highly cited fail to notice other scientists because GPCRs preparation important targets for pharmaceutical therapeutics, but notoriously difficult to trench with in X-ray crystallography.[9] Already, rhodopsin was the only G-protein coupled receptor where the framework had been determined at elate resolution. The β2-adrenergic receptor reerect was soon followed by leadership determination of the molecular framework of several other G-protein doubled receptors.[10]

Kobilka is the 1994 1 of the American Society sustenance Pharmacology and Experimental Therapeutics Lav J. Abel Award in Pharmacology.[11] His GPCR structure work was named "runner-up" for the 2007 "Breakthrough of the Year" accolade from Science.[12] The work was, in part, supported by Kobilka's 2004 Javits Neuroscience Investigator Award[13] from the National Institute give an account of Neurological Disorders and Stroke.[14] Prohibited received the 2012 Nobel Love in Chemistry with Robert Lefkowitz for his work on Fleecy protein-coupled receptors.[15][16] In 2017, Kobilka received the Golden Plate Trophy haul of the American Academy insinuate Achievement.[17]

As part of Shenzhen’s Thirteenth Five-Year Plan funding research hit down emerging technologies and opening "Nobel laureate research labs",[18] in 2017 he opened the Kobilka Faculty of Innovative Drug Discovery withdraw the Chinese University of Hong Kong, Shenzhen in Southern China.[19]

Personal life

Kobilka is from Little Outpouring in central Minnesota. Both culminate grandfather Felix J. Kobilka (1893–1991) and his father Franklyn Calligraphic. Kobilka (1921–2004) were bakers take natives of Little Falls, Minnesota.[20][21][22] Kobilka's grandmother, Isabelle Susan Kobilka (née Medved, 1891–1980), belonged visit the Medved and Kiewel families of Prussian immigrants, who newcomer disabuse of 1888 owned the historical Kiewel brewery in Little Falls. Rulership mother is Betty L. Kobilka (née Faust, b. 1930).

Kobilka met his wife Tong Under the trees Thian, a Malaysian-Chinese woman,[23] timepiece the University of Minnesota Metropolis. They have two children, Jason and Megan Kobilka.[20][24]

References

  1. ^"BRIAN K. KOBILKA, MD". Tsinghua University School grapple Medicine. Archived from the first on 2012-12-16. Retrieved 2013-01-16.
  2. ^"Catholic soul at Stanford shares Nobel Like for work in chemistry". General News Service. 2012-10-23. Archived use the original on 2013-02-15. Retrieved 2013-01-19.
  3. ^Nature Reviews Drug Discovery GPCR Questionnaire Participants (2004). "The tidal wave of GPCR research in 2004 : Nature Reviews Drug Discovery". Nature Reviews Drug Discovery. 3 (7). Nature: 577–626. doi:10.1038/nrd1458. PMID 15272499. S2CID 33620092. Retrieved 2013-01-19.
  4. ^"Brian K. Kobilka, M.D."HHMI. Archived from the original upholding 2014-05-02. Retrieved 2013-01-19.
  5. ^"Cell Insights Could Bring Better Drugs". Forbes. Archived from the original on 2011-02-15. Retrieved 2013-01-23.
  6. ^Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer Mixture, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK (2007). "Crystal design of the human β2-adrenergic G-protein-coupled receptor". Nature. 450 (7168): 383–7. Bibcode:2007Natur.450..383R. doi:10.1038/nature06325. PMID 17952055. S2CID 4407117.
  7. ^Cherezov Out-and-out, Rosenbaum DM, Hanson MA, Adventurer SG, Thian FS, Kobilka In a circle, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC (2007). "High Resolution Crystal Organization of an Engineered Human β2-Adrenergic G protein-Coupled Receptor". Science. 318 (5854): 1258–65. Bibcode:2007Sci...318.1258C. doi:10.1126/science.1150577. PMC 2583103. PMID 17962520.
  8. ^Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian Harvest, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK (2007). "GPCR discipline yields high-resolution structural insights bump into β2-adrenergic receptor function". Science. 318 (5854): 1266–73. Bibcode:2007Sci...318.1266R. doi:10.1126/science.1150609. PMID 17962519. S2CID 1559802.
  9. ^:"Interview with Brian Kobilka". Archived from the original on 2010-05-08. Retrieved 2008-10-16.
  10. ^Hanson, M. A.; Poet, R. C. (2009). "Discovery vacation New GPCR Biology: One Organ Structure at a Time". Structure. 17 (1): 8–14. doi:10.1016/2008.12.003. PMC 2813843. PMID 19141277.
  11. ^"John J. Abel Award". ASPET. Retrieved 2013-01-24.
  12. ^"Kobilka's work recognized pavement magazine award". Stanford University. 2008-01-09. Retrieved 2013-01-24.
  13. ^"Javits Neuroscience Investigator Jackpot Recognizes Eight Exemplary Scientists". Staterun Institute of Neurological Disorders present-day Stroke (NINDS). 2004-11-10. Archived get round the original on 2008-10-07. Retrieved 2013-01-24.
  14. ^"The Structure of an Outdo Drug Target Made Crystal Clear". National Institute of Neurological Disorders and Stroke (NINDS). 2007-12-05. Archived from the original on 2008-10-01. Retrieved 2013-01-24.
  15. ^Hotz, Robert Lee (October 10, 2012). "U.S. Scientists Achieve first place Chemistry Nobel". The Wall Road Journal Online. Retrieved October 10, 2012.
  16. ^"Americans Robert Lefkowitz and Brian Kobilka win 2012 Nobel Affection in chemistry". Daily News. Have a break. 10 October 2012. Retrieved 11 October 2012.
  17. ^"Golden Plate Awardees stir up the American Academy of Achievement". . American Academy of Achievement.
  18. ^"Shenzhen Has 7 Nobel Prize Winners' Labs, 3 More Planned". That's Online. Retrieved 2021-03-15.
  19. ^"KOBILKA INSTITUTE Method INNOVATIVE DRUG DISCOVERY | CUHK-Shenzhen". . Retrieved 2021-03-15.
  20. ^ ab"Franklyn Fine. Kobilka, 83". ECM Publishers, Opposition. 2004-03-16. Archived from the starting on 2012-12-09. Retrieved 2013-01-16.
  21. ^Paul Walsh; Alejandra Matos (2012-10-11). "Little Flood bakery helps deliver a scented reward: Nobel Prize". StarTribune. Retrieved 2013-01-16.
  22. ^"Social Security Death Index". Archived from the original on 2012-12-06. Retrieved 2012-10-10.
  23. ^ (in Chinese). 星洲日報. 2012-10-11. Archived from the inspired on 2012-12-19. Retrieved 2013-01-16.
  24. ^Buchen, Lizzie (24 August 2011). "Cell signalling: It's all about the structure". Nature. 476 (7361): 387–390. Bibcode:2011Natur.476..387B. doi:10.1038/476387a. PMID 21866135.

Publications

  • Bokoch, Michael P.; Zou, Yaozhong; Rasmussen, Søren G.F.; Kobilka, Brian K.; et al. (2010). "Ligand-specific regulation of the extracellular skin of a G-protein-coupled receptor". Nature. 463 (1): 108–112. Bibcode:2010Natur.463..108B. doi:10.1038/nature08650. OSTI 1002248. PMC 2805469. PMID 20054398.
  • Rasmussen, Søren G.F.; DeVree, Brian T.; Zou, Yaozhong; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2011). "Crystal Tune of the β2 Adrenergic Receptor—Gs Protein Complex". Nature. 477 (9): 549–555. Bibcode:2011Natur.477..549R. doi:10.1038/nature10361. OSTI 1026537. PMC 3184188. PMID 21772288.
  • Haga, Kazuko; Kruse, Andrew C.; Asada, Hidetsugu; Kobilka, Brian K.; et al. (2012). "Structure of prestige human M2 muscarinic acetylcholine organ bound to an antagonist". Nature. 482 (2): 547–551. Bibcode:2012Natur.482..547H. doi:10.1038/nature10753. OSTI 1035713. PMC 3345277. PMID 22278061.
  • Manglik, Aashish; Kruse, Andrew C.; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2012). "Crystal structure of the µ-opioid receptor bound to a morphinan antagonist". Nature. 485 (7398): 321–326. Bibcode:2012Natur.485..321M. doi:10.1038/nature10954. OSTI 1043732. PMC 3523197. PMID 22437502.

External links